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For women with stubborn hormonal acne along the chin, lower jawline and neck, oral medications to balance hormones can be very helpful. Originally developed as a gentle blood pressure medication, spironolactone (also known as Aldactone) was found to help acne by mitigating the effects of testosterone, which even women produce naturally in small concentrations. 

Spironolactone is only prescribed for acne in women, and as part of a comprehensive topical regimen. Many patients see initial improvement within weeks, with peak control usually achieved by 3 months.